Understanding the Root Causes of POTS and How Functional Medicine Treats It

Postural Orthostatic Tachycardia Syndrome (POTS) is a condition that affects the autonomic nervous system, leading to an abnormal increase in heart rate upon standing. Common symptoms include dizziness, fatigue, brain fog, heart palpitations, and exercise intolerance. While conventional medicine often manages POTS with medications and lifestyle adjustments, functional medicine seeks to uncover the root causes and address them holistically.

Root Causes of POTS

  1. Dysautonomia and Nervous System Imbalance
    POTS is classified under dysautonomia, a disorder where the autonomic nervous system fails to regulate functions like blood pressure and heart rate properly. This may stem from chronic stress, infections, or nervous system dysfunction.
  2. Autoimmune Dysfunction
    Many POTS patients exhibit autoimmune markers, suggesting that the body’s immune system may mistakenly attack its own nervous system, contributing to symptoms. Conditions like lupus, Sjögren’s syndrome, and autoimmune thyroid disorders are commonly linked to POTS.
  3. Chronic Infections
    Bacterial and viral infections such as Epstein-Barr virus (EBV), Lyme disease, and COVID-19 have been implicated in triggering or exacerbating POTS symptoms. These infections can lead to persistent inflammation and immune system dysregulation.
  4. Mast Cell Activation Syndrome (MCAS)
    Some POTS patients suffer from MCAS, a condition where mast cells release excessive histamines, leading to inflammation, tachycardia, and other autonomic symptoms.
  5. Nutritional Deficiencies
    Deficiencies in key nutrients like B vitamins, magnesium, sodium, and iron can impair blood volume regulation, nervous system function, and overall energy production.
  6. Gut Health Imbalances
    Gut dysbiosis, leaky gut syndrome, and small intestinal bacterial overgrowth (SIBO) can contribute to systemic inflammation and autonomic dysfunction, aggravating POTS symptoms.
  7. Mold Exposure
    Chronic exposure to mold and mycotoxins can contribute to immune system dysregulation, inflammation, and autonomic nervous system dysfunction, worsening POTS symptoms.

How Functional Medicine Approaches POTS Treatment

Functional medicine aims to address the underlying causes rather than just managing symptoms. Here are key strategies used:

  1. Comprehensive Testing and Root Cause Analysis
    Functional medicine practitioners use advanced testing to identify infections, autoimmune markers, nutritional deficiencies, and gut imbalances.
  2. Balancing the Autonomic Nervous System
    Therapies such as vagus nerve stimulation, meditation, breathwork, and gentle exercise (like yoga or tai chi) help regulate autonomic function.
  3. Addressing Autoimmune and Inflammatory Triggers
    Reducing systemic inflammation through an anti-inflammatory diet, targeted supplements (like omega-3s and curcumin), and immune-balancing protocols can help manage symptoms.
  4. Treating Underlying Infections
    If chronic infections like EBV or Lyme are detected, functional medicine uses antimicrobial herbs, immune-supporting therapies, and gut microbiome restoration to help clear infections.
  5. Supporting Mast Cell Stability
    A low-histamine diet, quercetin, vitamin C, and specific antihistamine protocols can help reduce excessive mast cell activation.
  6. Optimizing Nutrition and Hydration
    Increasing electrolyte intake (sodium, potassium, magnesium), supporting mitochondrial function with B vitamins and CoQ10, and improving gut health through probiotics and digestive support are key.
  7. Addressing Mold Toxicity
    If mold exposure is identified, functional medicine may incorporate detoxification strategies, such as binders (activated charcoal, bentonite clay), infrared sauna therapy, and environmental remediation.
  8. Lifestyle Modifications
    Functional medicine emphasizes sleep hygiene, stress reduction, and gradual physical conditioning (such as recumbent biking or resistance training) to help improve overall autonomic function.

Conclusion

POTS is a complex condition with multiple root causes, making a personalized, holistic approach essential for long-term healing. Functional medicine provides hope by addressing underlying triggers such as infections, immune dysregulation, mold exposure, and nervous system imbalances. By taking a comprehensive, patient-centered approach, functional medicine helps individuals with POTS regain their quality of life and long-term well-being.

If you or a loved one are struggling with POTS, working with a functional medicine practitioner can help uncover the root causes and provide a tailored treatment plan for recovery.